{4-[4-(3-Amino-3-methyl-but-1-ynyl)-phenyl]-pyrimidin-2-yl}-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine → {4-[4-(3-Amino-3-methyl-butyl)-phenyl]-pyrimidin-2-yl}-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine

HRID 1434999Notes

Reaction equation

HRID 1434999 reaction equation
[NH2:1][C:2]([CH3:29])([CH3:28])[C:3]#[C:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][N:14]=[C:13]([NH:17][CH:18]3[CH2:23][C:22]([CH3:25])([CH3:24])[NH:21][C:20]([CH3:27])([CH3:26])[CH2:19]3)[N:12]=2)=[CH:7][CH:6]=1>CCO.[Pd]>[NH2:1][C:2]([CH3:29])([CH3:28])[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][N:14]=[C:13]([NH:17][CH:18]3[CH2:23][C:22]([CH3:25])([CH3:24])[NH:21][C:20]([CH3:27])([CH3:26])[CH2:19]3)[N:12]=2)=[CH:7][CH:6]=1

Participants

4

Reactant 1

HCID 57936257{4-[4-(3-Amino-3-methyl-but-1-ynyl)-phenyl]-pyrimidin-2-yl}-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine

Product 1

HCID 57936178{4-[4-(3-Amino-3-methyl-butyl)-phenyl]-pyrimidin-2-yl}-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The title compound was prepared by hydrogenation of {4-[4-(3-amino-3-methyl-but-1-ynyl)-phenyl]-pyrimidin-2-yl}-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine using Pd/C in EtOH.

Sources & evidence

ORD record
ord-6e3afac6c4614e3ca6b42091df976ec5
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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