Ammonia → HCID 57936263, compound

HRID 1435001Notes

Reaction equation

HRID 1435001 reaction equation
[CH3:1][C:2]1([CH3:28])[CH2:7][CH:6]([NH:8][C:9]2[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][C:23]([OH:25])=O)=[CH:17][CH:16]=3)[CH:12]=[CH:11][N:10]=2)[CH2:5][C:4]([CH3:27])([CH3:26])[NH:3]1.S(Cl)(Cl)=O.[NH3:33]>CO>[CH3:26][C:4]1([CH3:27])[CH2:5][CH:6]([NH:8][C:9]2[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][C:23]([NH2:33])=[O:25])=[CH:17][CH:16]=3)[CH:12]=[CH:11][N:10]=2)[CH2:7][C:2]([CH3:28])([CH3:1])[NH:3]1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 24386Thionyl ChlorideHCID 579362343-{4-[2-(2,2,6,6-Tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-phenyl}-propionic acid

Product 1

HCID 57936263HCID 57936263, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared from 3-{4-[2-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-phenyl}-propionic acid (Step A of Example 185) and thionyl chloride followed by ammonia in MeOH. Yield: 5.3 mg (11%).

Sources & evidence

ORD record
ord-28f28273a06b486a9a799b631a1833c4
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

Loading…