Sodium Sulfate → HCID 57936185, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 3-{4-[2-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-phenyl}-propionic acid (50 mg, 0.13 mmol) (Step A of Example 185) in 1 ml THF was added LAH (1M in THF, 393 μl, 0.393 mmol). The mixture was stirred at 60° C. for 1 hour. A saturated solution of sodium sulfate was added and the aqueous phase was extracted with EtOAc. The crude product was purified using preparative HPLC. Yield: 19 mg (39%).

Provenance & Evidence