Methanol → {4-[4-(3-Methoxy-propyl)-phenyl]-pyrimidin-2-yl}-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine

HRID 1435006Notes

Reaction equation

HRID 1435006 reaction equation
[CH3:1][C:2]1([CH3:37])[CH2:7][CH:6]([NH:8][C:9]2[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][CH2:23][O:24]S(C4C=CC(C)=CC=4)(=O)=O)=[CH:17][CH:16]=3)[CH:12]=[CH:11][N:10]=2)[CH2:5][C:4]([CH3:36])([CH3:35])[NH:3]1.[CH3:38]O>>[CH3:38][O:24][CH2:23][CH2:22][CH2:21][C:18]1[CH:17]=[CH:16][C:15]([C:13]2[CH:12]=[CH:11][N:10]=[C:9]([NH:8][CH:6]3[CH2:7][C:2]([CH3:37])([CH3:1])[NH:3][C:4]([CH3:35])([CH3:36])[CH2:5]3)[N:14]=2)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 887MethanolHCID 57936242Toluene-4-sulfonic acid 3-{4-[2-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-phenyl}-propyl ester

Product 1

HCID 57936295{4-[4-(3-Methoxy-propyl)-phenyl]-pyrimidin-2-yl}-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine

Procedure

The title compound was prepared from toluene-4-sulfonic acid 3-{4-[2-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-phenyl}-propyl ester (Step A of Example 190) in MeOH. Yield: 3 mg (6%).

Sources & evidence

ORD record
ord-f343c89807a44ff3b43780dc862928bb
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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