Potassium Iodide → 4-{4-[2-(2,2,6,6-Tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-phenyl}-butyronitrile

Participants

Reaction Steps

A solution of toluene-4-sulfonic acid 3-{4-[2-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-phenyl}-propyl ester (80 mg, 0.15 mmol), (Step A of Example 190), KCN (20 mg, 0.31 mmol) and a catalytic amount of potassium iodide in 2 ml DMSO was stirred for 2 hours at 100° C. The reaction mixture was diluted with EtOAc and washed with water. The crude product was purified using preparative TLC. Yield: 9 mg (16%).

Provenance & Evidence