Sodium borohydride → 4-{4-[2-(2,2,6,6-Tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-phenyl}-butan-2-ol

HRID 1435010Notes

Reaction equation

HRID 1435010 reaction equation
[CH3:1][C:2]1([CH3:28])[CH2:7][CH:6]([NH:8][C:9]2[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][C:23](=[O:25])[CH3:24])=[CH:17][CH:16]=3)[CH:12]=[CH:11][N:10]=2)[CH2:5][C:4]([CH3:27])([CH3:26])[NH:3]1.[BH4-].[Na+]>CO>[CH3:27][C:4]1([CH3:26])[CH2:5][CH:6]([NH:8][C:9]2[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][CH:23]([OH:25])[CH3:24])=[CH:17][CH:16]=3)[CH:12]=[CH:11][N:10]=2)[CH2:7][C:2]([CH3:28])([CH3:1])[NH:3]1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 579363344-{4-[2-(2,2,6,6-Tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-phenyl}-butan-2-one

Product 1

HCID 579362304-{4-[2-(2,2,6,6-Tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-phenyl}-butan-2-ol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared by reduction of 4-{4-[2-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-phenyl}-butan-2-one with sodium borohydride in MeOH. Yield: 196 mg (100%).

Sources & evidence

ORD record
ord-a68e17c376c14215a1b20bac202cf044
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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