Indole → (4-Indol-1-yl-pyrimidin-2-yl)-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine

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Reaction Conditions

Reaction Steps

A mixture of (4-chloro-pyrimidin-2-yl)-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine (200 mg, 0.74 mmol), indole (96 μl, 0.81 mmol), potassium hydroxide (63 mg, 1.10 mmol) and a few drops of Aliquat 336 were heated to 120° C. for 5 h. After cooling to room temperature the mixture was dissolved in ethylacetate, washed with water and brine and the crude product was purified by HPLC. Thus 71 mg (0.20 mmol, 27%) of the title compound were obtained.

Provenance & Evidence