HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrabutylammonium Fluoride → HCID 57936216, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | {1-[tert-Butyl(dimethyl)silyl]-1H-indol-3-yl}boronic acid | HCID 10989478 | — |
| Reactant | (4-Chloro-pyrimidin-2-yl)(2,2,6,6-tetramethyl-piperidin-4-yl)-amine | HCID 57936167 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Product | HCID 57936216 | HCID 57936216 | — |
Reaction Steps
The title compound was prepared analogous to Step C of Method C, starting from (4-chloro-pyrimidin-2-yl)(2,2,6,6-tetramethyl-piperidin-4-yl)-amine and [1-(tert-butyl-dimethyl-silanyl)-1H-indol-3-yl]-boronic acid using bis(triphenylphosphine)palladium(II) dichloride as a catalyst. The TBDMS protecting group was cleaved in situ by addition of catalytic amounts of TBAF. Yield: 2.2 g (86%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07615562B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-610f8439e67b499fbc7400fbc8b785e5 |
| Source note | uspto-grants-2009_11 |