Boron tribromide → HCID 57936168, compound

Participants

Reaction Conditions

Reaction Steps

[4-(6-Methoxy-1H-indol-3-yl)-pyrimidin-2-yl]-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine (150 mg, 0.4 mmol) was suspended in 6 ml of DCM under argon. After cooling to 0° C., boron tribromide (1.64 ml of a 1M solution in DCM, 1.64 mmol) was added slowly. The cooling bath was removed after 30 minutes and stirring was continued for 16 hours. The reaction was quenched by adding 8 ml of MeOH at 0° C. and the product crystallised from this solution in form of its hydrobromide salt. Yield: 155 mg (94%).

Provenance & Evidence