Tetrabutylammonium Fluoride → HCID 57936144, compound

HRID 1435041Notes

Reaction equation

HRID 1435041 reaction equation
[F:1][C:2]1[C:10]([F:11])=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][CH:3]=1.Cl[C:13]1[CH:18]=[CH:17][N:16]=[C:15]([NH:19][CH:20]2[CH2:25][C:24]([CH3:27])([CH3:26])[NH:23][C:22]([CH3:29])([CH3:28])[CH2:21]2)[N:14]=1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>[F:1][C:2]1[C:10]([F:11])=[C:9]2[C:5]([C:6]([C:17]3[CH:18]=[CH:13][N:14]=[C:15]([NH:19][CH:20]4[CH2:25][C:24]([CH3:27])([CH3:26])[NH:23][C:22]([CH3:29])([CH3:28])[CH2:21]4)[N:16]=3)=[CH:7][NH:8]2)=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 2724141Tetrabutylammonium FluorideHCID 225957416,7-Difluoro-1H-indoleHCID 57936167(4-Chloro-pyrimidin-2-yl)(2,2,6,6-tetramethyl-piperidin-4-yl)-amine

Product 1

HCID 57936144HCID 57936144, compound

Procedure

The title compound was prepared as described in Example 215, starting from SEM-protected 6,7-difluoro-1H-indole and (4-chloro-pyrimidin-2-yl)-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine, followed by cleavage of the SEM-protecting group with TBAF. Yield: 100 mg (27%).

Sources & evidence

ORD record
ord-65d6e1fa1af14e8fbd5d0132aed0ce2f
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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