Tetrabutylammonium Fluoride → 3-[2-(2,2,6,6-Tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-1H-indole-7-carbonitrile

Participants

Role	Name	HCID	Charge
Reactant	Tetrabutylammonium Fluoride	HCID 2724141	—
Reactant	1H-Indole-7-carbonitrile	HCID 10898816	—
Reactant	(4-Chloro-pyrimidin-2-yl)(2,2,6,6-tetramethyl-piperidin-4-yl)-amine	HCID 57936167	—
Product	3-[2-(2,2,6,6-Tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-1H-indole-7-carbonitrile	HCID 57936301	—

Reaction Steps

The title compound was prepared as described in Example 215, starting from SEM-protected 1H-indole-7-carbonitrile and (4-chloro-pyrimidin-2-yl)-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine, followed by cleavage of the SEM-protecting group with TBAF. Yield: 10 mg (6%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07615562B2
Source dataset	uspto-grants-2009_11
ORD ID	ord-82135456a7b54f21858b70bf689b5ffc
Source note	uspto-grants-2009_11