Tetrabutylammonium Fluoride → HCID 57936177, compound

HRID 1435048Notes

Reaction equation

HRID 1435048 reaction equation
[CH3:1][NH:2][S:3]([C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:14]=1[NH:13][CH:12]=[CH:11]2)(=[O:5])=[O:4].Cl[C:16]1[CH:21]=[CH:20][N:19]=[C:18]([NH:22][CH:23]2[CH2:28][C:27]([CH3:30])([CH3:29])[NH:26][C:25]([CH3:32])([CH3:31])[CH2:24]2)[N:17]=1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>[CH3:1][NH:2][S:3]([C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:14]=1[NH:13][CH:12]=[C:11]2[C:20]1[CH:21]=[CH:16][N:17]=[C:18]([NH:22][CH:23]2[CH2:28][C:27]([CH3:30])([CH3:29])[NH:26][C:25]([CH3:32])([CH3:31])[CH2:24]2)[N:19]=1)(=[O:5])=[O:4]

Participants

4

Reactant 3

HCID 2724141Tetrabutylammonium FluorideHCID 14024592HCID 14024592, compoundHCID 57936167(4-Chloro-pyrimidin-2-yl)(2,2,6,6-tetramethyl-piperidin-4-yl)-amine

Product 1

HCID 57936177HCID 57936177, compound

Procedure

The title compound was prepared as described in Example 215, starting from SEM-protected 1H-indole-7-sulfonic acid methylamide and (4-chloro-pyrimidin-2-yl)(2,2,6,6-tetramethyl-piperidin-4-yl)-amine, followed by cleavage of the SEM-protecting groups with TBAF. Yield: 70 mg (5%).

Sources & evidence

ORD record
ord-8a2afec8c72d41a1ad437718b1363279
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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