4-Amino-1-aza-spiro[5.5]undecane-1-carboxylic acid tert-butyl ester → HCID 57936173, compound

HRID 1435049Notes

Reaction equation

HRID 1435049 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[C:7]2[C:11]1[CH:16]=[CH:15][N:14]=[C:13](Cl)[N:12]=1.C(OC([N:25]1[C:30]2([CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]2)[CH2:29][CH:28]([NH2:36])[CH2:27][CH2:26]1)=O)(C)(C)C>>[NH:25]1[C:30]2([CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]2)[CH2:29][CH:28]([NH:36][C:13]2[N:12]=[C:11]([C:7]3[C:6]4[C:10](=[C:2]([F:1])[CH:3]=[CH:4][CH:5]=4)[NH:9][CH:8]=3)[CH:16]=[CH:15][N:14]=2)[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 162287134-Amino-1-aza-spiro[5.5]undecane-1-carboxylic acid tert-butyl esterHCID 86610960HCID 86610960, compound

Product 1

HCID 57936173HCID 57936173, compound

Procedure

The racemic title compound was prepared as described in Example 244, starting from 7-Fluoro-3-(2-chloro-pyrimidin-4-yl)-1H-indole and 4-amino-1-aza-spiro[5.5]undecane-1-carboxylic acid tert-butyl ester from step A.

Sources & evidence

ORD record
ord-c00c99d1acf847c89dcd616bf65887d1
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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