2-Methyl-3-buten-2-ol → HCID 57936198, compound

HRID 1435052Notes

Reaction equation

HRID 1435052 reaction equation
Cl[C:2]1[CH:3]=[C:4]([F:28])[CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[C:7]2[C:11]1[CH:16]=[CH:15][N:14]=[C:13]([NH:17][CH:18]2[CH2:23][C:22]([CH3:25])([CH3:24])[NH:21][C:20]([CH3:27])([CH3:26])[CH2:19]2)[N:12]=1.[CH3:29][C:30]([OH:34])([CH:32]=[CH2:33])[CH3:31].CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>[F:28][C:4]1[CH:5]=[C:6]2[C:10](=[C:2](/[CH:33]=[CH:32]/[C:30]([CH3:31])([OH:34])[CH3:29])[CH:3]=1)[NH:9][CH:8]=[C:7]2[C:11]1[CH:16]=[CH:15][N:14]=[C:13]([NH:17][CH:18]2[CH2:19][C:20]([CH3:27])([CH3:26])[NH:21][C:22]([CH3:25])([CH3:24])[CH2:23]2)[N:12]=1

Participants

4

Reactant 3

HCID 82572-Methyl-3-buten-2-olHCID 2724141Tetrabutylammonium FluorideHCID 57936194HCID 57936194, compound

Product 1

HCID 57936198HCID 57936198, compound

Procedure

The title compound was prepared by the general Heck procedure described in Example 256, using the SEM-protected intermediate of Example 254 and 2-methyl-but-3-en-2-ol, followed by TBAF deprotection of the SEM group.

Sources & evidence

ORD record
ord-02942ff5abe04d48b525e42ea2918d82
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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