1-Vinylimidazole → HCID 57936265, compound

HRID 1435054Notes

Reaction equation

HRID 1435054 reaction equation
Cl[C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]3[CH:16]=[CH:15][N:14]=[C:13]([NH:17][CH:18]4[CH2:23][C:22]([CH3:25])([CH3:24])[NH:21][C:20]([CH3:27])([CH3:26])[CH2:19]4)[N:12]=3)=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[CH:28]([N:30]1[CH:34]=[CH:33][N:32]=[CH:31]1)=[CH2:29].CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>[N:30]1(/[CH:28]=[CH:29]/[C:2]2[CH:10]=[C:9]3[C:5]([C:6]([C:11]4[CH:16]=[CH:15][N:14]=[C:13]([NH:17][CH:18]5[CH2:19][C:20]([CH3:27])([CH3:26])[NH:21][C:22]([CH3:24])([CH3:25])[CH2:23]5)[N:12]=4)=[CH:7][NH:8]3)=[CH:4][CH:3]=2)[CH:34]=[CH:33][N:32]=[CH:31]1

Participants

4

Reactant 3

HCID 661711-VinylimidazoleHCID 2724141Tetrabutylammonium FluorideHCID 57936120HCID 57936120, compound

Product 1

HCID 57936265HCID 57936265, compound

Procedure

The title compound was prepared by the general Heck procedure described in Example 256, using the SEM-protected intermediate of Example 229 and 1-vinyl-1H-imidazole, followed by TBAF deprotection of the SEM group.

Sources & evidence

ORD record
ord-ff89cebe1fbf4a258e45237db7dee1f8
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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