Hydrogen Peroxide → HCID 57937844, compound

Participants

Reaction Steps

(4′-Cyano-3,5-difluoro-2′-methyl-biphenyl-4-ylmethyl)-(3-methyl-butyl)-carbamic acid tert-butyl ester (I-1d: 30 g) was dissolved in 150 mL dimethyl sulfoxide and combined with potassium carbonate (20 g) and 20 mL of a 30% hydrogen peroxide solution in water. After stirring at room temperature for 12 hours, the reaction mixture was quenched with water and extracted using ethyl acetate (250 mL). The organic layer was washed with water (2 times), brine, dried over magnesium sulfate, filtered and concentrated. The residue was purified by chromatography on silica eluting with 50% ethyl acetate in heptane to provide 28 g of the title compound (I-1e).

Provenance & Evidence