Hydrogen Peroxide → HCID 57937832, compound

Participants

Reaction Steps

(3-Chloro-4′-cyano-2′-methyl-biphenyl-4-ylmethyl)-(3-methyl-butyl)-carbamic acid tert-butyl ester (I-3d) was dissolved in 100 mL dimethyl sulfoxide (DMSO) and to which was added potassium carbonate and 4.0 mL of 30% hydrogen peroxide in water. The reaction was stirred at room temperature for 2 hours. The reaction was quenched with water and extracted using ethyl acetate (2 times). The combined organic layers were washed with water (5 times), brine, dried over sodium sulfate, filtered and concentrated. The product (I-3e) was isolated by dissolving the crude product in ethyl acetate and addition of heptane.

Provenance & Evidence