Hydrogen Peroxide → HCID 57937843, compound

Participants

Reaction Steps

(3′-Cyano-2-fluoro-biphenyl-4-ylmethyl)-(3-methyl-butyl)-carbamic acid tert-butyl ester (I-5d: 1.20 g, 3.02 mmol) was dissolved in dimethyl sulfoxide (5.5 ml) and treated with potassium carbonate (0.502 g, 3.6 mmol) and 0.250 ml of a 30% hydrogen peroxide solution. After 18 hours, the reaction mixture was diluted with water and extracted with ethyl acetate (3×). The combined organic layers were washed with water and brine, dried over sodium sulfate, filtered and concentrated under reduced pressure to afford the title compound (1.25 g, 99%), which was pure enough to be taken on and used directly in the next reaction.

Provenance & Evidence