Sodium borohydride → HCID 68900893, compound

Participants

Reaction Steps

2′-Chloro-4′-formyl-biphenyl-3-carbonitrile (I-6b: 6.0 g) was dissolved in 150 mL of methanol before sodium borohydride (3.4 g) was added gradually. After 1 hour, the reaction mixture was concentrated under reduced pressure, the resulting residue was taken up in 100 mL of ethyl acetated and washed twice with 20 mL of water. The organic phase was dried over magnesium sulfate, filtered, and concentrated under reduced pressure to afford the title compound (I-6c).

Provenance & Evidence