L-Serine → L-Alanine

HRID 1435101Notes

Reaction equation

HRID 1435101 reaction equation
[NH2:1][C@H:2]([C:5]([OH:7])=[O:6])[CH2:3]O.N[C@H:9]([C:17]([OH:19])=[O:18])[CH2:10][CH2:11][CH2:12][NH:13]C(=N)N.N[C@H:21]([C:26]([OH:28])=[O:27])[C@H](CC)C.[NH2:29][C@H:30]([C:35]([OH:37])=[O:36])[CH2:31][CH:32]([CH3:34])[CH3:33]>>[NH2:1][C@H:2]([C:5]([OH:7])=[O:6])[CH3:3].[NH2:1][C@H:2]([C:5]([O-:7])=[O:6])[CH2:3][C:17]([O-:19])=[O:18].[NH2:1][C@H:2]([C:5]([O-:7])=[O:6])[CH2:3][CH2:21][C:26]([O-:28])=[O:27].[NH2:29][C@H:30]([C:35]([OH:37])=[O:36])[CH2:31][C:32]1[C:34]2[C:12](=[CH:11][CH:10]=[CH:9][CH:17]=2)[NH:13][CH:33]=1

Participants

8

Reactant 4

HCID 5951L-SerineHCID 6106L-LeucineHCID 6306L-IsoleucineHCID 178418600HCID 178418600, compound

Product 4

HCID 5950L-AlanineHCID 6305L-TryptophanHCID 5460541l-aspartic acid, sodium saltHCID 5460544L-glutamate(2-)

Procedure

As shown in FIG. 2, the only amino acids that were significantly depleted from the medium during the compacting 8-cell to the morula stage were serine, arginine, isoleucine and leucine. Alanine, aspartate, glutamate and tryptophan were significantly produced. Alanine appearance increased from 10.87±1.61 pmol/embryo/h for embryos cultured between the compacting 8-cell to the morula stage compared to 13.90±1.23 pmol/embryo/h for embryos cultured from the morula to blastocyst stage.

Sources & evidence

ORD record
ord-507939d8253e4f668956063802331d53
Source dataset
uspto-grants-2009_11
Patent number
US07615677B2

Reaction notes

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