HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 57937544, compound → Methyl 3-hydroxy-5-[5-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-benzimidazol-1-yl]-2-thiophenecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 57937544 | HCID 57937544 | — |
| Reactant | methyl 3-[(1R)-1-(2-chloro-3-hydroxyphenyl)ethoxy]-5-(6-cyano-1H-benzimidazol-1-yl)thiophene-2-carboxylate | HCID 68565973 | — |
| Product | Methyl 3-hydroxy-5-[5-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-benzimidazol-1-yl]-2-thiophenecarboxylate | HCID 57937502 | 81.9% |
Reaction Steps
The title compound was prepared from methyl 3-{[(1R)-1-(2-chlorophenyl) ethyl]oxy}-5-[5-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-benzimidazol-1-yl]-2-thiophenecarboxylate (139 mg) using a procedure analogous to Intermediate 3, Step D to give 82.0 mg of the desired product. MS (ESI): 357 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07615643B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-dc46d7c7336c4875b752f60ecfd8f67d |
| Source note | uspto-grants-2009_11 |