HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propyl chloroformate → 4-[4-Amino-5-(2-methoxy-benzoyl)-pyrimidin-2-ylamino]-piperidine-1-carboxylic acid propyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propyl chloroformate | HCID 7998 | — |
| Reactant | [4-Amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(2-methoxy-phenyl)-methanone trifluoroacetic acid salt | HCID 69014044 | — |
| Product | 4-[4-Amino-5-(2-methoxy-benzoyl)-pyrimidin-2-ylamino]-piperidine-1-carboxylic acid propyl ester | HCID 10409491 | — |
Reaction Steps
The same procedure as described in Example 17 was used, starting from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(2-methoxy-phenyl)-methanone trifluoroacetic acid salt, Example 11, and propylchloroformate (Aldrich), to afford 4-[4-amino-5-(2-methoxy-benzoyl)-pyrimidin-2-ylamino]-piperidine-1-carboxylic acid propyl ester. HRMS, observed: 414.2140; Calcd for (M+H)+: 414.2136.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07615634B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-555c6cbc5f3948cdbca4b5e2d151ad40 |
| Source note | uspto-grants-2009_11 |