HuagongsheHuagongshe Chemistry Print Report · For research reference only
[4-Amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(2-methoxy-phenyl)-methanone trifluoroacetic acid salt → 1-[4-[4-Amino-5-(2-methoxy-benzoyl)-pyrimidin-2-ylamino]-piperidin-1-yl]-3-diethylamino-propan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [4-Amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(2-methoxy-phenyl)-methanone trifluoroacetic acid salt | HCID 69014044 | — |
| Reactant | Diethylaminopropionic acid hydrochloride | HCID 86594006 | — |
| Product | 1-[4-[4-Amino-5-(2-methoxy-benzoyl)-pyrimidin-2-ylamino]-piperidin-1-yl]-3-diethylamino-propan-1-one | HCID 21070358 | — |
Reaction Steps
The same procedure as described in Example 20 was used, starting from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(2-methoxy-phenyl)-methanone trifluoroacetic acid salt, Example 11, and diethylaminopropionic acid hydrochloride (Aldrich), to give 1-[4-[4-amino-5-(2-methoxy-benzoyl)-pyrimidin-2-ylamino]-piperidin-1-yl]-3-diethylamino-propan-1-one. HRMS, observed: 455.2769; Calcd for (M+H)+: 455.2765.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07615634B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-f74ae52d01d245debd4fa2b9681fcc12 |
| Source note | uspto-grants-2009_11 |