HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Iodotoluene → (4-Amino-2-ethylsulfanyl-pyrimidin-5-yl)-o-tolyl-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Iodotoluene | HCID 5128 | — |
| Reactant | 5-Pyrimidinecarboxamide, 4-amino-2-(ethylthio)-N-methoxy-N-methyl- | HCID 11974832 | — |
| Reactant | C7H7Li | HCID 178506678 | — |
| Product | (4-Amino-2-ethylsulfanyl-pyrimidin-5-yl)-o-tolyl-methanone | HCID 11975322 | — |
Reaction Steps
The same procedure was used as described in Example 2, starting from 4-amino-2-ethylsulfanyl-pyrimidine-5-carboxylic acid methoxy-methyl-amide (from Example 1) and a solution of 2-tolyllithium (˜3 equiv, freshly prepared from 2-iodotoluene, as in Example 2A), to give (4-amino-2-ethylsulfanyl-pyrimidin-5-yl)-o-tolyl-methanone as a white solid. MS (M+H)+: 274.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07615634B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-c99ad3d9b1e54afb9b7974dd868fbf74 |
| Source note | uspto-grants-2009_11 |