1-Propanesulfonyl chloride → HCID 10072505, compound

HRID 1435205Notes

Reaction equation

HRID 1435205 reaction equation
FC(F)(F)C(O)=O.[NH2:8][C:9]1[C:14]([C:15]([C:17]2[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:18]=2[O:24][CH3:25])=[O:16])=[CH:13][N:12]=[C:11]([NH:26][CH:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[N:10]=1.[CH2:33]([S:36](Cl)(=[O:38])=[O:37])[CH2:34][CH3:35]>>[NH2:8][C:9]1[C:14]([C:15]([C:17]2[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:18]=2[O:24][CH3:25])=[O:16])=[CH:13][N:12]=[C:11]([NH:26][CH:27]2[CH2:28][CH2:29][N:30]([S:36]([CH2:33][CH2:34][CH3:35])(=[O:38])=[O:37])[CH2:31][CH2:32]2)[N:10]=1

Participants

3

Reactant 2

HCID 662791-Propanesulfonyl chlorideHCID 21070627[4-Amino-2-(piperidin4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt

Product 1

HCID 10072505HCID 10072505, compound

Procedure

The same procedure as described in Example 60 was used, starting from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt, Example 59, and 1-propanesulfonyl chloride (Aldrich), to give [4-amino-2-[ 1-(propane-1-sulfonyl)-piperidin-4-ylamino]-pyrimidin-5-yl]-(5-fluoro-methoxy-phenyl)-methanone. MS (M+H)+, 452.

Sources & evidence

ORD record
ord-d5692955b6fd4314970c535148688d5e
Source dataset
uspto-grants-2009_11
Patent number
US07615634B2

Reaction notes

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