4-Amino-1-Boc-piperidine → HCID 58777641, compound

HRID 1435218Notes

Reaction equation

HRID 1435218 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[C:15]([F:16])=[CH:14][CH:13]=[C:12]([O:17][CH3:18])[C:11]=2[F:19])=[O:9])=[CH:6][N:5]=[C:4](S(CC)(=O)=O)[N:3]=1.[NH2:25][CH:26]1[CH2:31][CH2:30][N:29]([C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[CH2:28][CH2:27]1>>[C:35]([O:34][C:32]([N:29]1[CH2:30][CH2:31][CH:26]([NH:25][C:4]2[N:3]=[C:2]([NH2:1])[C:7]([C:8](=[O:9])[C:10]3[C:15]([F:16])=[CH:14][CH:13]=[C:12]([O:17][CH3:18])[C:11]=3[F:19])=[CH:6][N:5]=2)[CH2:27][CH2:28]1)=[O:33])([CH3:38])([CH3:36])[CH3:37]

Participants

3

Reactant 2

HCID 12682914-Amino-1-Boc-piperidineHCID 21070569HCID 21070569, compound

Product 1

HCID 58777641HCID 58777641, compound

Procedure

The same procedure was used as described in Example 90 starting from (4-amino-2-ethanesulfonyl-pyrimidin-5-yl)-(2,6-difluoro-3-methoxy-phenyl)-methanone, Example 89, and 4-amino-1-Boc-piperidine (Astatech) to give 4-[4-amino-5-(2,6-difluoro-3-methoxy-benzoyl)-pyrimidin-2-ylamino]-piperidine-1-carboxylic acid tert-butyl ester. MS (M+H)+, 464.

Sources & evidence

ORD record
ord-e4c887195a52490797c9cad078262a6d
Source dataset
uspto-grants-2009_11
Patent number
US07615634B2

Reaction notes

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