Cis tert-Butyl 4-aminocyclohexylcarbamate → HCID 178491845, compound

HRID 1435227Notes

Reaction equation

HRID 1435227 reaction equation
C(O[C:6](=O)[NH:7][CH:8]1[CH2:13][CH2:12][CH:11]([NH2:14])[CH2:10][CH2:9]1)(C)(C)C.[NH2:16][C:17]1[C:22]([C:23]([C:25]2[C:30]([O:31][CH3:32])=[CH:29][CH:28]=[C:27]([F:33])[C:26]=2[F:34])=[O:24])=[CH:21][N:20]=C(S(CC)(=O)=O)[N:18]=1>>[NH2:18][C:17]1[C:22]([C:23]([C:25]2[C:30]([O:31][CH3:32])=[CH:29][CH:28]=[C:27]([F:33])[C:26]=2[F:34])=[O:24])=[CH:21][N:20]=[C:6]([NH:7][C@H:8]2[CH2:9][CH2:10][C@H:11]([NH2:14])[CH2:12][CH2:13]2)[N:16]=1

Participants

3

Reactant 2

HCID 2756050Cis tert-Butyl 4-aminocyclohexylcarbamateHCID 11975080HCID 11975080, compound

Product 1

HCID 178491845HCID 178491845, compound

Procedure

The title compound was prepared as in Example 113 and Example 114 using (4-amino-cyclohexyl)-carbamic acid tert-butyl ester (Altech) and (4-amino-2-ethanesulfonyl-pyrimidin-5-yl)-(2,3-difluoro-6-methoxy-phenyl)-methanone Example 103. MS (M+H)+=378.

Sources & evidence

ORD record
ord-14f266bb4e1340508cc10345ecc3d5f0
Source dataset
uspto-grants-2009_11
Patent number
US07615634B2

Reaction notes

Loading…