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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1435252Generated: November 2, 2026

1,2,3-Trifluoro-5-methoxybenzene → (4-Amino-2-ethylsulfanyl-pyrimidin-5-yl)-(2,3,4-trifluoro-6-methoxy-phenyl)-methanone

https://huagongshe.com/reaction/1435252

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,2,3-Trifluoro-5-methoxybenzeneHCID 2776946—
Reactant5-Pyrimidinecarboxamide, 4-amino-2-(ethylthio)-N-methoxy-N-methyl-HCID 11974832—
Product(4-Amino-2-ethylsulfanyl-pyrimidin-5-yl)-(2,3,4-trifluoro-6-methoxy-phenyl)-methanoneHCID 11975325—

Reaction Steps

The compound was prepared from 4-amino-2-ethylsulfanyl-pyrimidine-5-carboxylic acid methoxy-methyl-amide, Example 1, and 3,4,5-trifluoroanisole (Aldrich) in an analogous manner as described in Example 169.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07615634B2
Source datasetuspto-grants-2009_11
ORD IDord-0ac1fb67bd8c49b08816b8087d6bfa61
Source noteuspto-grants-2009_11