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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1435255Generated: October 30, 2026

2-Bromo-4-fluorotoluene → (4-Amino-2-ethylsulfanyl-pyrimidin-5-yl)-(5-fluoro-2-methyl-phenyl)-methanone

https://huagongshe.com/reaction/1435255

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-4-fluorotolueneHCID 74016—
Reactant5-Pyrimidinecarboxamide, 4-amino-2-(ethylthio)-N-methoxy-N-methyl-HCID 11974832—
Product(4-Amino-2-ethylsulfanyl-pyrimidin-5-yl)-(5-fluoro-2-methyl-phenyl)-methanoneHCID 21070590—

Reaction Steps

The compound was prepared from 4-amino-2-ethylsulfanyl-pyrimidine-5-carboxylic acid methoxy-methyl-amide, Example 1, and 2-bromo4-fluorotoluene (Aldrich) in an analogous manner as described in Example 169.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07615634B2
Source datasetuspto-grants-2009_11
ORD IDord-67ffa6a693194718894408ab84e0b546
Source noteuspto-grants-2009_11