1-Bromo-2-methoxy-4-(trifluoromethyl)benzene → (4-Amino-2-methylsulfanyl-pyrimidin-5-yl)-(2-methoxy-4-trifluoromethyl-phenyl)-methanone

HRID 1435260Notes

Reaction equation

HRID 1435260 reaction equation
CON(C)[C:4]([C:6]1[C:7]([NH2:15])=[N:8][C:9]([S:12][CH2:13]C)=[N:10][CH:11]=1)=[O:5].Br[C:18]1[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][C:19]=1[O:28][CH3:29]>>[NH2:15][C:7]1[C:6]([C:4]([C:18]2[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][C:19]=2[O:28][CH3:29])=[O:5])=[CH:11][N:10]=[C:9]([S:12][CH3:13])[N:8]=1

Participants

3

Reactant 2

HCID 49911451-Bromo-2-methoxy-4-(trifluoromethyl)benzeneHCID 119748325-Pyrimidinecarboxamide, 4-amino-2-(ethylthio)-N-methoxy-N-methyl-

Product 1

HCID 21070611(4-Amino-2-methylsulfanyl-pyrimidin-5-yl)-(2-methoxy-4-trifluoromethyl-phenyl)-methanone

Procedure

The compound was prepared from 4-amino-2-ethylsulfanyl-pyrimidine-5-carboxylic acid methoxy-methyl-amide, Example 1, and 1-bromo-2-methoxy-4-trifluoromethyl-benzene (prepared from 3-(trifluoromethyl)-anisole, Aldrich) in an analogous manner as described in Example 169.

Sources & evidence

ORD record
ord-991e3411a86d4b98a97a94359f4d881d
Source dataset
uspto-grants-2009_11
Patent number
US07615634B2

Reaction notes

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