[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetate → HCID 58777627, compound

HRID 1435264Notes

Reaction equation

HRID 1435264 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[S:11][CH:12]=[CH:13][C:14]=2[CH3:15])=[O:9])=[CH:6][N:5]=[C:4](S(CC)=O)[N:3]=1.FC(F)(F)C(O)=O.[CH3:27][S:28]([N:31]1[CH2:36][CH2:35][CH:34]([NH2:37])[CH2:33][CH2:32]1)(=[O:30])=[O:29]>>[NH2:1][C:2]1[C:7]([C:8]([C:10]2[S:11][CH:12]=[CH:13][C:14]=2[CH3:15])=[O:9])=[CH:6][N:5]=[C:4]([NH:37][CH:34]2[CH2:35][CH2:36][N:31]([S:28]([CH3:27])(=[O:30])=[O:29])[CH2:32][CH2:33]2)[N:3]=1

Participants

3

Reactant 2

HCID 11975076[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetateHCID 21070599HCID 21070599, compound

Product 1

HCID 58777627HCID 58777627, compound

Procedure

The compound was prepared from (4-amino-2-ethylsulfinyl-pyrimidin-5-yl)-(3-methyl-thiophen-2-yl)-methanone (Example 197) and 1-methanesulfonyl-piperidin-4-ylamine; compound with trifluoroacetic acid (Example 162) in an analogous manner as described in Example 172. HR-MS (ES, m/z) calculated for C16H22N5O3S2 [(M+H)+] 396.1159, observed 396.1162.

Sources & evidence

ORD record
ord-a607799be23f46d78dc777bdeefd6555
Source dataset
uspto-grants-2009_11
Patent number
US07615634B2

Reaction notes

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