HuagongsheHuagongshe Chemistry Print Report · For research reference only
[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetate → [4-Amino-2-(1-methanesulfonyl-piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-isopropoxy-phenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetate | HCID 11975076 | — |
| Reactant | (4-Amino-2-ethylsulfinyl-pyrimidin-5-yl)-(5-fluoro-2-isopropoxy-phenyl)-methanone | HCID 21070600 | — |
| Product | [4-Amino-2-(1-methanesulfonyl-piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-isopropoxy-phenyl)-methanone | HCID 10072504 | — |
Reaction Steps
The compound was prepared from (4-amino-2-ethylsulfinyl-pyrimidin-5-yl)-(5-fluoro-2-isopropoxy-phenyl)-methanone (Example 200) and 1-methanesulfonyl-piperidin-4-ylamine; compound with trifluoroacetic acid (Example 162) in an analogous manner as described in Example 172. HR-MS (ES, m/z) calculated for C20H27N5O4SF [(M+H)+] 452.1766, observed 452.1766.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07615634B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-4ec1ddda89654918aa55d5c482139a5d |
| Source note | uspto-grants-2009_11 |