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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1435285Generated: October 31, 2026

(R)-(-)-2-Amino-1-propanol → HCID 10098850, compound

https://huagongshe.com/reaction/1435285

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(R)-(-)-2-Amino-1-propanolHCID 80308—
Reactant[4-Amino-2-[1-(3-chloro-propane-1-sulfonyl)-piperidin-4-ylamino]-pyrimidin-5-yl]-(2,3-difluoro-6-methoxy-phenyl)-methanoneHCID 9983584—
ProductHCID 10098850HCID 10098850—

Reaction Steps

The compound was prepared from [4-amino-2-[1-(3-chloro-propane-1-sulfonyl)-piperidin-4-ylamino]-pyrimidin-5-yl]-(2,3-difluoro-6-methoxy-phenyl)-methanone (Example 226) and (R)-2-amino-1-propanol (Aldrich) in an analogous manner as described in Example 227. HR-MS (ES, m/z) calculated for C23H33N6O5SF2[(M+H)+] 543.2196, observed 543.2201.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07615634B2
Source datasetuspto-grants-2009_11
ORD IDord-b0b8f71e555e46489951b0db94c99b7f
Source noteuspto-grants-2009_11