(2-Methoxyethyl)(methyl)amine → [4-Amino-2-(1-[3-[(2-methoxy-ethyl)-methyl-amino]-propane-1-sulfonyl]-piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone

Participants

Role	Name	HCID	Charge
Reactant	(2-Methoxyethyl)(methyl)amine	HCID 300977	—
Reactant	[4-Amino-2-[1-(3-chloro-propane-1-sulfonyl)-piperidin-4-ylamino]-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone	HCID 10458099	—
Product	[4-Amino-2-(1-[3-[(2-methoxy-ethyl)-methyl-amino]-propane-1-sulfonyl]-piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone	HCID 10030161	—

Reaction Steps

The compound was prepared from [4-amino-2-[1-(3-chloro-propane-1-sulfonyl)-piperidin-4-ylamino]-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone (Example 242) and N-(2-methoxyethyl)methylamine (TCI America) in an analogous manner as described in Example 227. HR-MS (ES, m/z) calculated for C24H36N6O5SF [(M+H)+] 539.2447, observed 539.2449.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07615634B2
Source dataset	uspto-grants-2009_11
ORD ID	ord-36ad412997114a719a86af67327ebd96
Source note	uspto-grants-2009_11