4-Chlorobutane-1-sulphonyl chloride → HCID 58777553, compound

HRID 1435300Notes

Reaction equation

HRID 1435300 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=2[O:17][CH3:18])=[O:9])=[CH:6][N:5]=[C:4]([NH:19][CH:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[N:3]=1.[Cl:26][CH2:27][CH2:28][CH2:29][CH2:30][S:31](Cl)(=[O:33])=[O:32]>>[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=2[O:17][CH3:18])=[O:9])=[CH:6][N:5]=[C:4]([NH:19][CH:20]2[CH2:21][CH2:22][N:23]([S:31]([CH2:30][CH2:29][CH2:28][CH2:27][Cl:26])(=[O:33])=[O:32])[CH2:24][CH2:25]2)[N:3]=1

Participants

3

Reactant 2

HCID 742124-Chlorobutane-1-sulphonyl chlorideHCID 9997668[4-Amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone

Product 1

HCID 58777553HCID 58777553, compound

Procedure

The compound was prepared from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone (Example 59) and 4-chloro-butane-1-sulfonyl chloride (Example 254) in an analogous manner as described in Example 177. HR-MS (ES, m/z) calculated for C21H27N5O4SFCI [(M+H)+]500.1532, observed 500.1529.

Sources & evidence

ORD record
ord-f9da71a48e334a6d9d13f024665c0ac0
Source dataset
uspto-grants-2009_11
Patent number
US07615634B2

Reaction notes

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