Potassium Iodide → HCID 178491843, compound

Participants

Reaction Steps

The chloride (530 mg, 1.02 mmol, Example 293) was dissolved in tetrahydrofuran (8 mL). To it was added potassium t-butoxide (395 mg, 3.53 mmol, Aldrich) and potassium iodide (10 mg). The mixture was heated at reflux for 3 hours and the reaction was quenched with 0.5N hydrochloric acid (1 mL). The mixture was extracted with ethyl acetate (3×10 mL) and the extracts were combined and dried with sodium sulfate. Removal of solvent gave the crude which was chromatographed (5% methanol/dichloromethane) to give a pale yellow solid. 412 mg, 85%. MS (ES) MH+=482. CDK4 IC50=0.005 μM; CDK1 IC50=0.028 μM; CDK2 IC50=0.008 μM; HCT 116 IC90=0.320 μM.

Provenance & Evidence