Methanesulfonyl chloride → HCID 21070481, compound

HRID 1435368Notes

Reaction equation

[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[C:14]([CH3:16])[CH:13]=[CH:12][C:11]=2[O:17][CH3:18])=[O:9])=[CH:6][N:5]=[C:4]([NH:19][CH:20]2[CH2:25][CH2:24][CH:23]([NH2:26])[CH2:22][CH2:21]2)[N:3]=1.[CH3:27][S:28](Cl)(=[O:30])=[O:29]>>[NH2:1][C:2]1[C:7]([C:8](=[O:9])[C:10]2[CH:15]=[C:14]([CH3:16])[CH:13]=[CH:12][C:11]=2[O:17][CH3:18])=[CH:6][N:5]=[C:4]([NH:19][CH:20]2[CH2:25][CH2:24][CH:23]([NH:26][S:28]([CH3:27])(=[O:30])=[O:29])[CH2:22][CH2:21]2)[N:3]=1

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 21070475HCID 21070475, compound

Product 1

HCID 21070481HCID 21070481, compound

Procedure

A similar procedure as described in Example 60 was used, starting from [4-amino-2-(4-amino-cyclohexylamino)-pyrimidin-5-yl]-(2-methoxy-5-methyl-phenyl)-methanone (Example 337) and methanesulfonyl chloride (Aldrich) to give N-[4-[4-amino-5-(2-methoxy-5-methyl-benzoyl)-pyrimidin-2-ylamino]-cyclohexyl]-methanesulfonamide. MS (M+H)+, 398.

Sources & evidence

ORD record: ord-a4fae644fbf74c708d593e397975ed29
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07615634B2

Reaction notes

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