HCID 21070567, compound → HCID 58777554, compound

HRID 1435372Notes

Reaction equation

HRID 1435372 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[C:14]([F:16])[C:13]([CH3:17])=[CH:12][C:11]=2[O:18][CH3:19])=[O:9])=[CH:6][N:5]=[C:4](S(CC)=O)[N:3]=1.[C:24]([O:28][C:29](=[O:38])[NH:30][C@H:31]1[CH2:36][CH2:35][C@H:34]([NH2:37])[CH2:33][CH2:32]1)([CH3:27])([CH3:26])[CH3:25]>>[C:24]([O:28][C:29](=[O:38])[NH:30][CH:31]1[CH2:32][CH2:33][CH:34]([NH:37][C:4]2[N:3]=[C:2]([NH2:1])[C:7]([C:8](=[O:9])[C:10]3[CH:15]=[C:14]([F:16])[C:13]([CH3:17])=[CH:12][C:11]=3[O:18][CH3:19])=[CH:6][N:5]=2)[CH2:35][CH2:36]1)([CH3:27])([CH3:25])[CH3:26]

Participants

3

Reactant 2

HCID 21070567HCID 21070567, compoundHCID 178419079HCID 178419079, compound

Product 1

HCID 58777554HCID 58777554, compound

Procedure

The same procedure as described in Example 326 was used, starting with (4-amino-2-ethanesulfinyl-pyrimidin-5-yl)-(5-fluoro-2-methoxy-4-methyl-phenyl)-methanone (Example 341) and (trans4-amino-cyclohexyl)-carbamic acid tert-butyl ester (Astatech) to give [4-[4-amino-5-(5-fluoro-2-methoxy-4-methyl-benzoyl)-pyrimidin-2-ylamino]-cyclohexyl]-carbamic acid tert-butyl ester as a white solid. MS (M+H)+, 474

Sources & evidence

ORD record
ord-7d2109cd954b4fd1bd56ed88b3e546f8
Source dataset
uspto-grants-2009_11
Patent number
US07615634B2

Reaction notes

Loading…