Methanesulfonyl chloride → HCID 21070483, compound

HRID 1435374Notes

Reaction equation

[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[C:14]([F:16])[C:13]([CH3:17])=[CH:12][C:11]=2[O:18][CH3:19])=[O:9])=[CH:6][N:5]=[C:4]([NH:20][CH:21]2[CH2:26][CH2:25][CH:24]([NH2:27])[CH2:23][CH2:22]2)[N:3]=1.[CH3:28][S:29](Cl)(=[O:31])=[O:30]>>[NH2:1][C:2]1[C:7]([C:8](=[O:9])[C:10]2[CH:15]=[C:14]([F:16])[C:13]([CH3:17])=[CH:12][C:11]=2[O:18][CH3:19])=[CH:6][N:5]=[C:4]([NH:20][CH:21]2[CH2:26][CH2:25][CH:24]([NH:27][S:29]([CH3:28])(=[O:31])=[O:30])[CH2:23][CH2:22]2)[N:3]=1

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 21070476HCID 21070476, compound

Product 1

HCID 21070483HCID 21070483, compound

Procedure

The similar procedure as described in Example 60 was used, starting from [4-amino-2-(4-amino-cyclohexylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-4-methyl-phenyl)-methanone (Example 345) and methanesulfonyl chloride (Aldrich) to give N-[4-[4-amino-5-(5-fluoro-2-methoxy-4-methyl-benzoyl)-pyrimidin-2-ylamino]-cyclohexyl]-methanesulfonamide. MS (M+H)+, 452.

Sources & evidence

ORD record: ord-73217d4b96bd4bce9a16f72be95ca3c0
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07615634B2

Reaction notes

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