HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-4,6-difluoroanisole → (4-Amino-2-ethylsulfanyl-pyrimidin-5-yl)-(3,5-difluoro-2-methoxy-phenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-4,6-difluoroanisole | HCID 2736263 | — |
| Reactant | 5-Pyrimidinecarboxamide, 4-amino-2-(ethylthio)-N-methoxy-N-methyl- | HCID 11974832 | — |
| Product | (4-Amino-2-ethylsulfanyl-pyrimidin-5-yl)-(3,5-difluoro-2-methoxy-phenyl)-methanone | HCID 21070578 | — |
Reaction Steps
The same procedure as described in Example 376 was used, starting with 4-amino-2-ethylsulfanyl-pyrimidine-5-carboxylic acid methoxy-methyl-amide (Example 1) and 2-bromo-4,6-difluoroanisole (Metrix) to give (4-amino-2-ethylsulfanyl-pyrimidin-5-yl)-(3,5-difluoro-2-methoxy-phenyl)-methanone. MS (M+H)+, 326.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07615634B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-4d1828a5067547f6b81d3344ddfc86be |
| Source note | uspto-grants-2009_11 |