N-{5-(acetylamino)-2-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}-2,2-dimethylbutanamide → HCID 57937317, compound

Participants

Reaction Steps

Following the same procedure in Example 1, Step F, using N-{5-(acetylamino)-2-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}-2,2-dimethylbutanamide (5.12 g, 14.2 mmol) in AcOH (60 mL). Yield: 2.30 g (47%). 1H NMR (400 MHz, CHLOROFORM-D): δ 0.78 (t, J=7.42 Hz, 3 H), 1.45-1.60 (m, 10 H), 1.86 (q, J=7.42 Hz, 2 H), 2.19 (s, 3 H), 2.22-2.37 (m, 1 H), 3.24-3.38 (m, 2 H), 3.91-4.02 (m, 2 H), 4.17 (d, J=7.42 Hz, 2 H), 7.26 (d, J=8.5 Hz, 1 H), 7.39 (s, 1 H), 7.53 (dd, J=8.69, 2.05 Hz, 1 H), 7.67 (d, J=1.95 Hz, 1 H); MS (ESI) (M+H)+=344.05.

Provenance & Evidence