Ethyl (3S)-piperidine-3-carboxylate → HCID 57937302, compound

Participants

Reaction Steps

2-tert-Butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole-5-sulfonyl chloride (1.2 g, 2.9 mmol) was slowly added to a solution of ethyl (3S)-piperidine-3-carboxylate (0.7 g, 4.4 mmol) and DIPLA (2.6 mL, 14 mmol) in DCL (50 mL) at 80° C. The reaction mixture was stirred for 1 h and the solvent was concentrated. The product was purified by MPLC on silica gel using 60-90% EtOAc/Heptane to provide the title compound as white solid. Yield: 1.5 g (96%); MS (ESI) (M+H)+=526.0.

Provenance & Evidence