Trifluoroacetic acid → HCID 57937360, compound

Participants

Reaction Steps

Following the same procedure in Example 37, Step A, using tert-butyl[1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)azetidin-3-yl]carbamate (0.34 g, 0.63 mmol) and TFA (5 mL) in CH2Cl2 (10 mL). Yield: 0.26 g (93%). 1H NMR (400 MHz, METHANOL-D4) δ 1.47-1.57 (m, 2 H), 1.61 (s, 9 H), 1.63-1.84 (m, 4 H), 1.98-2.13 (m, 2 H), 2.16-2.32 (m, 1 H), 3.79-3.90 (m, 3 H), 3.97-4.08 (m, 2 H), 4.45 (d, J=7.42 Hz, 2 H), 7.75-7.84 (m, 1 H), 7.86-7.92 (m, 1 H), 8.14 (d, J=1.37 Hz, 1 H); MS (ESI) (M+H)+=441.3; Anal. Calcd for C21H30F2N4O2S+2.10 TFA (680.01): C, 44.51; H, 4.76; N, 8.24. Found: C, 44.48; H, 4.65; N, 8.43.

Provenance & Evidence