HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 57937326, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-tert-Butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole-5-sulfonyl chloride | HCID 57937294 | — |
| Reactant | 3-Azetidineacetic acid hydrochloride | HCID 66615016 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 57937326 | HCID 57937326 | — |
Reaction Steps
Following the same procedure in Example 1, Step A, using 2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole-5-sulfonyl chloride (1.06 g, 2.6 mmol), azetidin-3-ylacetic acid hydrochloride (1.17 g, 7.8 mmol) and DIPEA (4 mL) in CH2Cl2 (20 mL), provided the title compound as crude product (930 mg, 74% yield), which was used directly in Step A.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07615642B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-c3d9f801cce141528eda0ac2e72fb244 |
| Source note | uspto-grants-2009_11 |