HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 5-Nitro-3-(phenylethynyl)pyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Phenylacetylene | HCID 10821 | — |
| Reactant | 2-Amino-3-bromo-5-nitropyridine | HCID 2734412 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Nitro-3-(phenylethynyl)pyridin-2-amine | HCID 59322901 | — |
Reaction Steps
1.83 g 2-amino-3-bromo-5-nitropyridine 0.29 g PdCl2(PPh3)2 and 79 mg CuI were mixed in 36 ml dry tetrahydrofuran (THF) and 3.45 ml triethylamine and 1.12 g phenylacetylene were added. Stirring was continued at room temperature for 12 hrs, then the solvent was removed and the residue purified by flash chromatography on silica in ethyl acetate/heptane eluent. Yield 855 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07618964B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-4d14ad169c804737b6cec9725c20d544 |
| Source note | uspto-grants-2009_11 |