3,4-Difluorobenzaldehyde → HCID 178526788, compound

HRID 1435590Notes

Reaction equation

HRID 1435590 reaction equation
[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=1.[F:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][C:20]=1[F:21])[CH:16]=O>[N+](C1C=CC=CC=1)([O-])=O>[F:12][C:13]1[CH:14]=[C:15]([C:16]2[NH:1][C:2]3=[N:3][CH:4]=[C:5]([N+:9]([O-:11])=[O:10])[CH:6]=[C:7]3[N:8]=2)[CH:18]=[CH:19][C:20]=1[F:21]

Participants

4

Reactant 2

HCID 5880883,4-DifluorobenzaldehydeHCID 34801515-Nitropyridine-2,3-diamine

Product 1

HCID 178526788HCID 178526788, compoundYield 27.9%

Reagents, catalysts & solvents 1

HCID 7416NitrobenzeneSolvent

Procedure

1.00 g 2,3-diamino-5-nitro-pyridine and 0.95 g 3,4-difluorobenzaldehyde were stirred in 60 ml nitrobenzene at 160 C for 26 hrs. The solvent was removed under vacuum and the residue dissolved in 40 ml pyridine at 60 C. The solution was cooled in an ice bath. Precipitated product was isolated by filtration and dried to yield 0.5 g of the title product.

Workup

  1. customThe solvent was removed under vacuum
  2. dissolutionthe residue dissolved in 40 ml pyridine at 60 C
  3. temperatureThe solution was cooled in an ice bath
  4. customPrecipitated product was isolated by filtration
  5. customdried

Sources & evidence

ORD record
ord-60eac8599e17403eb7aec7a750de281b
Source dataset
uspto-grants-2009_11
Patent number
US07618964B2

Reaction notes

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