4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 10134022, compound

HRID 1435611Notes

Reaction equation

HRID 1435611 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[Cl:13][C:14]1[C:15]([CH3:24])=[C:16]([S:20](Cl)(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=1>>[Cl:13][C:14]1[C:15]([CH3:24])=[C:16]([S:20]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 5227343-Chloro-2-methylbenzenesulfonyl chloride

Product 1

HCID 10134022HCID 10134022, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 3-chloro-2-methylbenzenesulfonyl chloride according to METHOD A at 30° C., using a Quest 210 apparatus. This procedure gave 2.05 g (34%) of an off-white solid: mp 154° C.; MS (Ionspray, [M+H]+) m/z 375; Anal. Calcd (found) for C14H15ClN2O4S2: C, 44.9 (45.0)%, H, 4.0 (3.7)%, N, 7.5 (7.1)%.

Sources & evidence

ORD record
ord-53ca93529df044419a49d9175e9d2c1a
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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