4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 10181072, compound

HRID 1435627Notes

Reaction equation

HRID 1435627 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[C:16]([Cl:21])[C:15]=1[S:22](Cl)(=[O:24])=[O:23]>>[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[C:16]([Cl:21])[C:15]=1[S:22]([NH:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1)(=[O:24])=[O:23]

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 5213352,4,6-Trichlorobenzenesulfonyl chloride

Product 1

HCID 10181072HCID 10181072, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 2,4,6-trichlorobenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (32.0 mg) with purity >90%: LCMS (pos) m/z 431.0; HRMS m/z 427.9238 (calc. of monoisotopic mass for C13H11Cl3N2O4S2 gives 427.9226).

Sources & evidence

ORD record
ord-f5abb80f52ca4816b89b0b67b3819762
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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