4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 3863162, compound

HRID 1435628Notes

Reaction equation

HRID 1435628 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:15]=1[S:21](Cl)(=[O:23])=[O:22]>>[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:15]=1[S:21]([NH:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1)(=[O:23])=[O:22]

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 204419Benzenesulfonyl chloride, 2,4-dichloro-

Product 1

HCID 3863162HCID 3863162, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 2,4-dichlorobenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (45.8 mg) with purity >90%. MS (pos) m/z 395.2, 397.2.

Sources & evidence

ORD record
ord-caddae0cc2fe47b0b6c8860284402ac7
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

Loading…