4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 10133028, compound

HRID 1435629Notes

Reaction equation

HRID 1435629 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[F:13][C:14]1[CH:15]=[CH:16][C:17]([CH3:24])=[C:18]([S:20](Cl)(=[O:22])=[O:21])[CH:19]=1>>[F:13][C:14]1[CH:15]=[CH:16][C:17]([CH3:24])=[C:18]([S:20]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:22])=[O:21])[CH:19]=1

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 1362865-Fluoro-2-methylbenzenesulphonyl chloride

Product 1

HCID 10133028HCID 10133028, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 5-fluoro-2-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (32.7 mg) with purity >90%. LCMS (pos) m/z 359.2.

Sources & evidence

ORD record
ord-65e10228ef834be7a6bc56ff3c922a5d
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

Loading…